| December 1, 2027 |
NVO |
A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in People With Reduced Liver Function and Normal Liver Function |
Trial Milestone |
Phase 1 |
| December 1, 2027 |
RVMD |
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301) |
Trial Milestone |
Phase 3 |
| December 1, 2027 |
REPL |
Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC |
Trial Milestone |
Phase 2 |
| December 1, 2027 |
QURE |
Safety, PK/PD, and Exploratory Efficacy Study of AMT-191 in Classic Fabry Disease |
Trial Milestone |
Phase 1/Phase 2 |
| December 1, 2027 |
ALMS |
Open-Label Extension Study to Evaluate the Long Term Safety and Efficacy of ESK-001 in Plaque Psoriasis |
Trial Milestone |
Phase 2 |
| December 2, 2027 |
PFE |
Study to Learn About Safety, Tolerability, and Immune Response of a Catch-up Pneumococcal Vaccine in Children and Adolescents |
Trial Milestone |
Phase 3 |
| December 2, 2027 |
PGEN |
Zopa Retreatment and Vector Shedding in Adults With RRP |
Trial Milestone |
Phase 4 |
| December 6, 2027 |
TAK |
A Study of TAK-755 in Adults With Acute Ischemic Stroke |
Trial Milestone |
Phase 2 |
| December 7, 2027 |
MRNA |
A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1010 in Healthy Children |
Trial Milestone |
Phase 1 |
| December 14, 2027 |
ALNY |
A Study to Evaluate ALN-6222 in Participants With Obesity |
Trial Milestone |
Phase 1 |
| December 15, 2027 |
JNJ |
A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT) |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
JNJ |
A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
ABBV |
A Study to Assess Disease Activity and Safety of Subcutaneous Lutikizumab (ABT-981) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-Tumor Necrosis Factor (TNF) Therapy and Who Are Naïve to Biologic Therapy |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
ABBV |
Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
ABBV |
Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
GILD |
Study With Various Immunotherapy Treatments in Participants With Lung Cancer |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
SVA |
Protective Efficacy , Immunogenicity and Safety of the Tetravalent Inactivated Enterovirus Vaccine (Vero Cell). |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
BNTX |
A Clinical Trial Testing the Safety of Pumitamig (an Investigational Drug) and How Well it Works When Combined With Chemotherapy for People Who Have Not Been Treated Yet for Pancreatic Cancer |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
VNDA |
Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies |
Trial Milestone |
Phase 1 |
| December 15, 2027 |
AAPG |
APG-2449 in Patients With Advanced Solid Tumors |
Trial Milestone |
Phase 1 |
| December 15, 2027 |
AAPG |
A Study of HQP1351 in Patients With GIST or Other Solid Tumors |
Trial Milestone |
Phase 1 |
| December 15, 2027 |
BMRN |
A Clinical Trial to Evaluate Safety of Vosoritide in At-risk Infants With Achondroplasia |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
BMRN |
A Study to Evaluate Long-Term Safety, Tolerability, & Efficacy of BMN 111 in Children With Achondroplasia (ACH) |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
BMRN |
AAV Gene Therapy Study for Subjects with PKU |
Trial Milestone |
Phase 1/Phase 2 |
| December 15, 2027 |
AXSM |
A Study to Assess the Long-term Safety and Efficacy of Solriamfetol in Subjects With Binge Eating Disorder |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
AXSM |
An Open-Label Study to Assess the Long-Term Safety of Solriamfetol in Children and Adolescents With ADHD |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
AXSM |
Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT) |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
IBRX |
Study of CD19 t-haNK and NAI With Rituximab in Participants With Indolent Non-Hodgkin Lymphoma |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
ARWR |
Study of Inhaled ARO-RAGE in Allergen-induced Mild Asthma |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
ASND |
A Clinical Trial to Evaluate Efficacy and Safety of TransCon CNP Compared With Placebo in Infants (0 to <2 Years of Age) With Achondroplasia |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
NTLA |
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM) |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
IOVA |
A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
PCVX |
A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 in Healthy Infants |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
PCVX |
A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-A1 in Healthy Young Adults |
Trial Milestone |
Phase 1 |
| December 15, 2027 |
IMVT |
Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
ANVS |
A Double-blind Dual Study Assessing Safety and Efficacy of Buntanetap in Participants With Early AD |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
CANF |
A Phase 3 Study in Moderate-to-Severe Plaque Psoriasis With Piclidenoson to Study Safety and Efficacy |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
DNLI |
A Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic (nMPS II) or Non-Neuronopathic Mucopolysaccharidosis Type II (nnMPS II) |
Trial Milestone |
Phase 2/Phase 3 |
| December 15, 2027 |
RNAC |
Descartes-08 for Children, Adolescents, and Young Adults With Autoimmune Disorders |
Trial Milestone |
Phase 1/Phase 2 |
| December 15, 2027 |
ALXO |
ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
OCS |
Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation Research |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
SNDX |
A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation |
Trial Milestone |
Phase 1/Phase 2 |
| December 15, 2027 |
CRBP |
A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
EWTX |
A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF) |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
EWTX |
A Study of EDG-7500 in Adults With Hypertrophic Cardiomyopathy (CIRRUS-HCM) |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
CRVS |
Safety and Efficacy of Soquelitinib in Adults With Hidradenitis Suppurativa |
Trial Milestone |
Phase 1 |
| December 15, 2027 |
KURA |
A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST) |
Trial Milestone |
Phase 1 |
| December 15, 2027 |
INTS |
A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3) |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
BCTX |
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer. |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
MPLT |
A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
NERV |
Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medications |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
RADX |
177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors |
Trial Milestone |
EARLY_Phase 1 |
| December 15, 2027 |
RADX |
HEAT Trial (HER2 Antibody Therapy With Lutetium-177) |
Trial Milestone |
EARLY_Phase 1 |
| December 15, 2027 |
RADX |
177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors |
Trial Milestone |
Phase 1/Phase 2 |
| December 15, 2027 |
KYMR |
A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
WVE |
A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity |
Trial Milestone |
Phase 1/Phase 2 |
| December 15, 2027 |
OTLK |
A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders |
Trial Milestone |
Phase 3 |
| December 15, 2027 |
TMCI |
A Study Comparing the MAGICTouch™ Sirolimus-coated Balloon With a Paclitaxel-coated Balloon for Treating Severe Narrowing or Blockage in the Femoropopliteal Arteries. |
Trial Milestone |
Phase 2/Phase 3 |
| December 15, 2027 |
MAZE |
A Study of MZE782 in Adults With PKU |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
XNCR |
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis |
Trial Milestone |
Phase 1/Phase 2 |
| December 15, 2027 |
XNCR |
Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors |
Trial Milestone |
Phase 1 |
| December 15, 2027 |
ALLO |
Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL |
Trial Milestone |
Phase 2 |
| December 15, 2027 |
GNPX |
Quaratusugene Ozeplasmid (Reqorsa) and Atezolizumab Maintenance Therapy in ES-SCLC Patients |
Trial Milestone |
Phase 1/Phase 2 |
| December 18, 2027 |
MRK |
A Clinical Study of V503 in Chinese Females Who Have Previously Received a Bivalent Human Papillomavirus (HPV) Vaccine (V503-108) |
Trial Milestone |
Phase 3 |
| December 23, 2027 |
JAZZ |
A Study Evaluating the Efficacy and Safety of Xywav Expanded Dosing vs Placebo in Participants With Narcolepsy or IH |
Trial Milestone |
Phase 3 |
| December 26, 2027 |
AMGN |
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION) |
Trial Milestone |
Phase 3 |
| December 27, 2027 |
ALNY |
TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy |
Trial Milestone |
Phase 3 |
| December 30, 2027 |
AMGN |
A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC) |
Trial Milestone |
Phase 2 |
| December 30, 2027 |
BEAM |
A Phase 1/2, Dose-Exploration Study to Evaluate the Safety and Efficacy of BEAM-301 in Patients With Glycogen Storage Disease Type Ia (GSDIa) |
Trial Milestone |
Phase 1/Phase 2 |
| December 30, 2027 |
RLAY |
A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors |
Trial Milestone |
Phase 1 |
| December 30, 2027 |
PBYI |
A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer |
Trial Milestone |
Phase 2 |
| December 30, 2027 |
MNKD |
Phase 2 Clinical Trial of MNKD-201 (Nintedanib Dry Powder Inhalation) in Patients With Idiopathic Pulmonary Fibrosis |
Trial Milestone |
Phase 2 |
| December 30, 2027 |
CGEM |
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Rheumatoid Arthritis |
Trial Milestone |
Phase 1 |
| December 31, 2027 |
ONC |
A Study of BG-C477 in Participants With Advanced Solid Tumors |
Trial Milestone |
Phase 1 |
| December 31, 2027 |
AAPG |
A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Efficacy of APG-5918. |
Trial Milestone |
Phase 1 |
| December 31, 2027 |
AAPG |
A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ ALL (POLARIS-1) |
Trial Milestone |
Phase 3 |
| December 31, 2027 |
INBS |
A Clinical Trial of BAT4406F Injection in Patients With Neuromyelitis Optica Spectrum Disorders |
Trial Milestone |
Phase 2 |
| December 31, 2027 |
GRFS |
A Study to Evaluate the Pharmacokinetics and Safety of XEMBIFY Versus Gamunex-C in Participants With Chronic Inflammatory Demyelinating Polyradiculoneuropathy |
Trial Milestone |
Phase 3 |
| December 31, 2027 |
ADRX |
Safety, Tolerability, PK, PD of ADX-324 in Healthy Volunteers and Hereditary Angioedema Patients |
Trial Milestone |
Phase 1/Phase 2 |
| December 31, 2027 |
SRPT |
A Gene Transfer Therapy Study to Evaluate the Safety of and Expression From Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD) - Non-Ambulatory Cohort |
Trial Milestone |
Phase 1 |
| December 31, 2027 |
SUPN |
Safety and Tolerability Study of SPN-817 in Adult Patients With Treatment Resistant Epilepsy |
Trial Milestone |
Phase 2 |
| December 31, 2027 |
SUPN |
SPN-817 Open-Label Extension Study in Adults With Focal Onset Seizures |
Trial Milestone |
Phase 2 |
| December 31, 2027 |
OLMA |
Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer |
Trial Milestone |
Phase 1 |
| December 31, 2027 |
KNSA |
Phase 2/3 Study of Participants With Recurrent Pericarditis Evaluating the Efficacy and Safety of KPL-387 |
Trial Milestone |
Phase 2/Phase 3 |
| December 31, 2027 |
KNSA |
Transition to KPL-387 Monotherapy Dosing & Administration Study |
Trial Milestone |
Phase 2 |
| December 31, 2027 |
CATX |
MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma |
Trial Milestone |
Phase 1/Phase 2 |